Sequence Detail

ID/Version

P0C090 A2AVP5 (UniProt | EBI)

Last sequence update: 2005-08-16
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Roquin-2; EC=2.3.2.27 {ECO:0000250|UniProtKB:Q9HBD1};AltName: Full=Membrane-associated nucleic acid-binding protein;AltName: Full=RING finger and CCCH-type zinc finger domain-containing protein 2;AltName: Full=RING-type E3 ubiquitin

Provider

SWISS-PROT

Sequence

Polypeptide 1187 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rc3h2	ring finger and CCCH-type zinc finger domains 2	44	97	3	26

Sequence references in MGI

J:196136 Vogel KU, et al., Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation. Immunity. 2013 Apr 18;38(4):655-68
J:196137 Pratama A, et al., Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation. Immunity. 2013 Apr 18;38(4):669-80
J:221791 Srivastava M, et al., Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis. Nat Commun. 2015;6:6253
J:259145 Jeltsch KM, et al., Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Nat Immunol. 2014 Nov;15(11):1079-89
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89