Sequence Detail

ID/Version

P09803 Q61377 (UniProt | EBI)

Last sequence update: 1989-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cadherin-1;AltName: Full=ARC-1;AltName: Full=Epithelial cadherin; Short=E-cadherin;AltName: Full=Uvomorulin;AltName: CD_antigen=CD324;Contains: RecName: Full=E-Cad/CTF1;Contains: RecName: Full=E-Cad/CTF2;Contains: RecName: Full=E-

Provider

SWISS-PROT

Sequence

Polypeptide 884 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdh1	cadherin 1	155	540	6	436

Sequence references in MGI

J:733 Ringwald M, et al., The structure of the gene coding for the mouse cell adhesion molecule uvomorulin. Nucleic Acids Res. 1991 Dec 11;19(23):6533-9
J:9009 Ringwald M, et al., The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion. EMBO J. 1987 Dec 1;6(12):3647-53
J:16882 Nagafuchi A, et al., Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature. 1987 Sep 24-30;329(6137):341-3
J:34510 Behrens J, et al., The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11495-9
J:35398 Munro SB, et al., A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction. Biol Reprod. 1996 Oct;55(4):822-7
J:37378 Butz S, et al., Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. FEBS Lett. 1994 Nov 28;355(2):195-200
J:56551 Lecuit M, et al., A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes. EMBO J. 1999 Jul 15;18(14):3956-63
J:136451 Sklyarova T, et al., Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. J Invest Dermatol. 2008 Jun;128(6):1375-85
J:162941 Sokabe T, et al., The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem. 2010 Jun 11;285(24):18749-58
J:182415 Huber AH, et al., The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell. 2001 May 4;105(3):391-402
J:238141 Keil R, et al., Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3. J Invest Dermatol. 2016 Oct;136(10):2022-9
J:248258 Abe K, et al., EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):13-9
J:276414 Defourny J, et al., EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions. iScience. 2019 Jan 25;11:246-257
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:326898 Choi HJ, et al., Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes. J Biol Chem. 2009 Nov 13;284(46):31776-88
J:345003 Cronan MR, et al., Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. Immunity. 2016 Oct 18;45(4):861-876