Sequence Detail

ID/Version

P09535 E9QLW5 (UniProt | EBI)

Last sequence update: 1989-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Insulin-like growth factor 2 {ECO:0000312|MGI:MGI:96434};AltName: Full=Insulin-like growth factor II {ECO:0000303|PubMed:1997210}; Short=IGF-II {ECO:0000303|PubMed:1702294};AltName: Full=Multiplication-stimulating polypeptide;Contain

Provider

SWISS-PROT

Sequence

Polypeptide 180 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Igf2	insulin-like growth factor 2	85	245	4	37

Sequence references in MGI

J:8474 Stempien MM, et al., Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor. DNA. 1986 Oct;5(5):357-61
J:10453 DeChiara TM, et al., A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature. 1990 May 3;345(6270):78-80
J:10904 Rotwein P, et al., Evolution of insulin-like growth factor II: characterization of the mouse IGF-II gene and identification of two pseudo-exons. DNA Cell Biol. 1990 Dec;9(10):725-35
J:11007 DeChiara TM, et al., Parental imprinting of the mouse insulin-like growth factor II gene. Cell. 1991 Feb 22;64(4):849-59
J:16204 Holthuizen PE, et al., Differential expression of the human, mouse and rat IGF-II genes. Regul Pept. 1993 Oct 20;48(1-2):77-89
J:40695 Sasaki H, et al., Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene. DNA Res. 1996 Oct 31;3(5):331-5
J:77386 Constancia M, et al., Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature. 2002 Jun 27;417(6892):945-8
J:156975 Datta K, et al., NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation. J Biol Chem. 2009 Oct 23;284(43):29666-76
J:243401 Wilson EM, et al., Control of MyoD function during initiation of muscle differentiation by an autocrine signaling pathway activated by insulin-like growth factor-II. J Biol Chem. 2006 Oct 06;281(40):29962-71
J:243423 Yang P, et al., A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568. Science. 2017 May 19;356(6339):757-759
J:265506 Younis S, et al., The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2048-E2057
J:296123 Younis S, et al., The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells. FASEB J. 2020 Jun 19;