Sequence Detail

ID/Version

P09242 Q6P1B0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Alkaline phosphatase, tissue-nonspecific isozyme {ECO:0000303|PubMed:10620060, ECO:0000303|PubMed:7789278}; Short=AP-TNAP; Short=TNAP {ECO:0000303|PubMed:7789278}; Short=TNSALP {ECO:0000303|PubMed:10620060}; E

Provider

SWISS-PROT

Sequence

Polypeptide 524 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alpl	alkaline phosphatase, liver/bone/kidney	67	127	3	296

Sequence references in MGI

J:8897 Terao M, et al., Cloning and characterization of a cDNA coding for mouse placental alkaline phosphatase. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7051-5
J:25249 MacGregor GR, et al., Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells. Development. 1995 May;121(5):1487-96
J:28394 Waymire KG, et al., Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6. Nat Genet. 1995 Sep;11(1):45-51
J:33620 Brown NA, et al., Induction of alkaline phosphatase in mouse L cells by overexpression of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1990 Aug 5;265(22):13181-9
J:39015 Narisawa S, et al., Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn. 1997 Mar;208(3):432-46
J:66842 Narisawa S, et al., Abnormal vitamin B6 metabolism in alkaline phosphatase knock-out mice causes multiple abnormalities, but not the impaired bone mineralization. J Pathol. 2001 Jan;193(1):125-33
J:77731 Hessle L, et al., Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9445-9
J:78130 Fedde KN, et al., Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. J Bone Miner Res. 1999 Dec;14(12):2015-26
J:88444 Anderson HC, et al., Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Am J Pathol. 2004 Mar;164(3):841-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:173678 Yadav MC, et al., Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification. J Bone Miner Res. 2011 Feb;26(2):286-97
J:179862 Ciancaglini P, et al., Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles. J Bone Miner Res. 2010 Apr;25(4):716-23
J:199822 Street SE, et al., Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord. J Neurosci. 2013 Jul 3;33(27):11314-22
J:233254 Narisawa S, et al., In vivo overexpression of tissue-nonspecific alkaline phosphatase increases skeletal mineralization and affects the phosphorylation status of osteopontin. J Bone Miner Res. 2013 Jul;28(7):1587-98
J:287360 Bessueille L, et al., Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase. Bone. 2020 Apr;133:115262
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298347 Nakamura T, et al., Tissue-nonspecific alkaline phosphatase promotes the osteogenic differentiation of osteoprogenitor cells. Biochem Biophys Res Commun. 2020 Apr 9;524(3):702-709
J:306607 Sun Y, et al., Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature. 2021 May;593(7860):580-585
J:314086 Pinkerton AB, et al., Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34
J:314565 Huesa C, et al., The Functional co-operativity of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 during initiation of Skeletal Mineralization. Biochem Biophys Rep. 2015 Dec 1;4:196-201
J:314754 Wennberg C, et al., Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice. J Bone Miner Res. 2000 Oct;15(10):1879-88
J:341423 Feng XY, et al., Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Eur J Oral Sci. 2018 Feb;126(1):1-12
J:341424 Feng XY, et al., Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. Eur J Oral Sci. 2013 Oct;121(5):412-20