Sequence Detail

ID/Version

P09055 Q3TWH6 Q8BVU1 Q3TIW5 Q8BTU0 Q60993 Q61126 F6R105 (UniProt | EBI)

Last sequence update: 1988-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Integrin beta-1 {ECO:0000305};AltName: Full=Fibronectin receptor subunit beta;AltName: Full=VLA-4 subunit beta;AltName: CD_antigen=CD29;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 798 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itgb1	integrin beta 1 (fibronectin receptor beta)	301	159	6	63

Sequence references in MGI

J:9382 Tominaga S, Murine mRNA for the beta-subunit of integrin is increased in BALB/c-3T3 cells entering the G1 phase from the G0 state. FEBS Lett. 1988 Oct 10;238(2):315-9
J:31505 Holers VM, et al., Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II. J Exp Med. 1989 May 1;169(5):1589-605
J:36129 Baudoin C, et al., Genomic organization of the mouse beta 1 gene: conservation of the beta 1D but not of the beta 1B and beta 1C integrin splice variants. Cell Adhes Commun. 1996 Jul;4(1):1-11
J:47279 Baudoin C, et al., Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. Genes Dev. 1998 Apr 15;12(8):1202-16
J:59402 Miyado K, et al., Requirement of CD9 on the egg plasma membrane for fertilization. Science. 2000 Jan 14;287(5451):321-4
J:59592 Belkin AM, et al., Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells. J Cell Biol. 1996 Jan;132(1-2):211-26
J:85292 Li J, et al., The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. Dev Biol. 2003 Sep 1;261(1):209-19
J:86753 Nakamura T, et al., Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 Jan 10;415(6868):171-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:134768 Montanez E, et al., Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 2008 May 15;22(10):1325-30
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:155307 Baruzzi A, et al., c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010 Jan 4;584(1):15-21
J:175678 Brunner M, et al., Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. J Cell Biol. 2011 Jul 25;194(2):307-22
J:188906 Prunier C, et al., Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J Biol Chem. 2005 Apr 29;280(17):17540-8
J:215661 Wadehra M, et al., The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J Biol Chem. 2002 Oct 25;277(43):41094-100
J:262023 Morooka N, et al., Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circ Res. 2017 Apr 14;120(8):1276-1288
J:273507 Muramatsu H, et al., alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor. J Cell Sci. 2004 Oct 15;117(Pt 22):5405-15
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314094 Luo W, et al., TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration. J Cachexia Sarcopenia Muscle. 2021 Aug 23;
J:315946 Sato-Nishiuchi R, et al., Polydom/SVEP1 is a ligand for integrin alpha9beta1. J Biol Chem. 2012 Jul 20;287(30):25615-30
J:333698 Morris GE, et al., The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins alpha9beta1 and alpha4beta1. Br J Pharmacol. 2022 Nov;179(21):4958-4973
J:334841 Kuramoto K, et al., Exercise-activated hepatic autophagy via the FN1-alpha5beta1 integrin pathway drives metabolic benefits of exercise. Cell Metab. 2023 Feb 14;
J:343785 Benedet PO, et al., CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation. EBioMedicine. 2023 Dec 6;99:104906