Sequence Detail

ID/Version

P08226 (UniProt | EBI)

Last sequence update: 1990-08-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Apolipoprotein E; Short=Apo-E;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 311 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Apoe	apolipoprotein E	340	134	4	86

Sequence references in MGI

J:2809 Plump AS, et al., Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992 Oct 16;71(2):343-53
J:8115 Rajavashisth TB, et al., Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit. Proc Natl Acad Sci U S A. 1985 Dec;82(23):8085-9
J:10005 Horiuchi K, et al., Structure and expression of mouse apolipoprotein E gene. J Biochem. 1989 Jul;106(1):98-103
J:42511 Diedrich JF, et al., Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes. J Virol. 1991 Sep;65(9):4759-68
J:81822 Lesnik P, et al., Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. J Clin Invest. 2003 Feb;111(3):333-40
J:158401 Stewart CR, et al., CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010 Feb;11(2):155-61
J:201440 Gonzales JC, et al., Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest. 2013 Jun 3;123(6):2742-51
J:205721 Sheedy FJ, et al., CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 2013 Aug;14(8):812-20
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:315405 van Niel G, et al., Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells. Cell Rep. 2015 Oct 6;13(1):43-51