Sequence Detail

ID/Version

P08152 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 SUMO-protein ligase EGR2; EC=2.3.2.- {ECO:0000250|UniProtKB:P11161};AltName: Full=E3 SUMO-protein transferase ERG2 {ECO:0000305};AltName: Full=Early growth response protein 2; Short=EGR-2;AltName: Full=Zinc finger protein

Provider

SWISS-PROT

Sequence

Polypeptide 470 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Egr2	early growth response 2	84	218	4	19

Sequence references in MGI

J:3739 Sham MH, et al., The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation. Cell. 1993 Jan 29;72(2):183-96
J:9144 Chavrier P, et al., A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J. 1988 Jan;7(1):29-35
J:9172 Chavrier P, et al., Characterization of a mouse multigene family that encodes zinc finger structures. Mol Cell Biol. 1988 Mar;8(3):1319-26
J:9740 Chavrier P, et al., Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos. Mol Cell Biol. 1989 Feb;9(2):787-97
J:21073 Topilko P, et al., Krox-20 controls myelination in the peripheral nervous system. Nature. 1994 Oct 27;371(6500):796-9
J:52990 Zorick TS, et al., Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells. Development. 1999 Apr;126(7):1397-406
J:116858 Turman JE Jr, et al., The Krox-20 null mutation differentially affects the development of masticatory muscles. Dev Neurosci. 2001;23(2):113-21
J:128960 Dillon RL, et al., An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Mol Cell Biol. 2007 Dec;27(24):8648-57
J:129790 Chen Z, et al., Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab. 2005 Feb;1(2):93-106
J:153775 Chen A, et al., The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. Mol Cell Biol. 2009 Oct;29(19):5348-56
J:285008 Grosz BR, et al., A de novo EGR2 variant, c.1232A > G p.Asp411Gly, causes severe early-onset Charcot-Marie-Tooth Neuropathy Type 3 (Dejerine-Sottas Neuropathy). Sci Rep. 2019 Dec 18;9(1):19336
J:285221 Manzanares M, et al., Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. EMBO J. 2002 Feb 1;21(3):365-76