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Sequence Detail
P08046 Q61777 (UniProt | EBI) Last sequence update: 1990-11-01
Last annotation update: 2020-02-26
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RecName: Full=Early growth response protein 1; Short=EGR-1;AltName: Full=Nerve growth factor-induced protein A {ECO:0000303|PubMed:1740423}; Short=NGFI-A {ECO:0000303|PubMed:1740423};AltName: Full=Transcription factor Zif268 {ECO:0000303|P
Polypeptide 533 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Egr1 early growth response 1 91 90 9 10
Sequence references in MGI J:9085 Sukhatme VP, et al., A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988 Apr 8;53(1):37-43
J:9240 Lemaire P, et al., Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4691-5
J:10113 Janssen-Timmen U, et al., Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24; evidence for a common regulatory pathway for immediate-early serum-response genes. Gene. 1989 Aug 15;80(2):325-36
J:26993 Christy BA, et al., A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with zinc finger sequences. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7857-61
J:34254 Gashler AL, et al., A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol Cell Biol. 1993 Aug;13(8):4556-71
J:35132 Lee SL, et al., Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science. 1996 Aug 30;273(5279):1219-21
J:66141 Yan SF, et al., Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med. 2000 Dec;6(12):1355-61
J:93996 Liao Y, et al., Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice. J Biol Chem. 2004 Oct 8;279(41):43107-16
J:99386 Krones-Herzig A, et al., Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Res. 2005 Jun 15;65(12):5133-43
J:267299 Riedel CS, et al., Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature. J Mol Neurosci. 2018 Jan;64(1):9-19
J:274077 Tao W, et al., EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription. Sci Rep. 2015 Oct 16;5:15212

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory