Sequence Detail

ID/Version

P07750 (UniProt | EBI)

Last sequence update: 1988-08-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Interleukin-4; Short=IL-4;AltName: Full=B-cell IgG differentiation factor;AltName: Full=B-cell growth factor 1;AltName: Full=B-cell stimulatory factor 1; Short=BSF-1;AltName: Full=IGG1 induction factor;AltName: Full=Lymphocyt

Provider

SWISS-PROT

Sequence

Polypeptide 140 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il4	interleukin 4	111	109	3	26

Sequence references in MGI

J:8210 Noma Y, et al., Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Nature. 1986 Feb 20-26;319(6055):640-6
J:8249 Lee F, et al., Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2061-5
J:8612 Otsuka T, et al., Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities. Nucleic Acids Res. 1987 Jan 12;15(1):333-44
J:31932 Kaplan MH, et al., Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 1996 Mar;4(3):313-9
J:52881 Sideras P, et al., IgG1 induction factor: a single molecular entity with multiple biological functions. Adv Exp Med Biol. 1987;213:227-36
J:227653 Terawaki S, et al., RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4. J Cell Biol. 2015 Sep 28;210(7):1133-52
J:244446 Edukulla R, et al., Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression. J Biol Chem. 2015 May 22;290(21):13510-20
J:252702 Brombacher TM, et al., IL-13-Mediated Regulation of Learning and Memory. J Immunol. 2017 Apr 01;198(7):2681-2688