Sequence Detail

ID/Version

P07147 (UniProt | EBI)

Last sequence update: 1988-04-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=5,6-dihydroxyindole-2-carboxylic acid oxidase; Short=DHICA oxidase {ECO:0000303|PubMed:7813420}; EC=1.14.18.- {ECO:0000269|PubMed:7813420};AltName: Full=Brown locus protein;AltName: Full=Catalase B;AltName: Full=Tyrosinase-re

Provider

SWISS-PROT

Sequence

Polypeptide 537 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tyrp1	tyrosinase-related protein 1	42	104	4	69

Sequence references in MGI

J:1962 Tsukamoto K, et al., A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase. EMBO J. 1992 Feb;11(2):519-26
J:8247 Shibahara S, et al., Cloning and expression of cDNA encoding mouse tyrosinase. Nucleic Acids Res. 1986 Mar 25;14(6):2413-27
J:9222 Jackson IJ, A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse [published erratum appears in Proc Natl Acad Sci U S A 1989 Feb;86(3):997]. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4392-6
J:14622 Halaban R, et al., Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4809-13
J:14831 Winder AJ, et al., The mouse brown (b) locus protein has dopachrome tautomerase activity and is located in lysosomes in transfected fibroblasts. J Cell Sci. 1993 Sep;106(Pt 1):153-66
J:44435 Zdarsky E, et al., The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type. Genetics. 1990 Oct;126(2):443-9
J:124026 Setty SR, et al., BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol Biol Cell. 2007 Mar;18(3):768-80
J:139015 Setty SR, et al., Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes. Nature. 2008 Aug 28;454(7208):1142-6
J:230050 Marubashi S, et al., RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016 Jan 15;291(3):1427-40
J:328663 Liu Y, et al., Ablation of Proton/Glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis. J Invest Dermatol. 2022 Apr 23;