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Sequence Detail
ID/Version
P07147 (UniProt | EBI) Last sequence update: 1988-04-01
Last annotation update: 2019-07-03
Sequence
description
from provider
RecName: Full=5,6-dihydroxyindole-2-carboxylic acid oxidase; Short=DHICA oxidase {ECO:0000303|PubMed:7813420}; EC=1.14.18.- {ECO:0000269|PubMed:7813420};AltName: Full=Brown locus protein;AltName: Full=Catalase B;AltName: Full=Tyrosinase-re
Provider SWISS-PROT
Sequence
Polypeptide 537 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Tyrp1 tyrosinase-related protein 1 32 7 10 65
Sequence references in MGI J:1962 Tsukamoto K, et al., A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase. EMBO J. 1992 Feb;11(2):519-26
J:8247 Shibahara S, et al., Cloning and expression of cDNA encoding mouse tyrosinase. Nucleic Acids Res. 1986 Mar 25;14(6):2413-27
J:9222 Jackson IJ, A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse [published erratum appears in Proc Natl Acad Sci U S A 1989 Feb;86(3):997]. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4392-6
J:14622 Halaban R, et al., Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4809-13
J:14831 Winder AJ, et al., The mouse brown (b) locus protein has dopachrome tautomerase activity and is located in lysosomes in transfected fibroblasts. J Cell Sci. 1993 Sep;106(Pt 1):153-66
J:44435 Zdarsky E, et al., The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type. Genetics. 1990 Oct;126(2):443-9
J:124026 Setty SR, et al., BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol Biol Cell. 2007 Mar;18(3):768-80
J:230050 Marubashi S, et al., RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016 Jan 15;291(3):1427-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory