Sequence Detail

ID/Version

P07141 Q8R3C8 Q3U395 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Macrophage colony-stimulating factor 1; Short=CSF-1; Short=MCSF;AltName: Full=Proteoglycan macrophage colony-stimulating factor {ECO:0000250|UniProtKB:P09603}; Short=PG-M-CSF {ECO:0000250|UniProtKB:P09603};Contains:

Provider

SWISS-PROT

Sequence

Polypeptide 552 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Csf1	colony stimulating factor 1 (macrophage)	115	118	4	20

Sequence references in MGI

J:8616 Rajavashisth TB, et al., Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1157-61
J:9333 Ladner MB, et al., cDNA cloning and expression of murine macrophage colony-stimulating factor from L929 cells. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6706-10
J:10519 Yoshida H, et al., The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature. 1990 May 31;345(6274):442-4
J:20231 DeLamarter JF, et al., Nucleotide sequence of a cDNA encoding murine CSF-1 (Macrophage-CSF). Nucleic Acids Res. 1987 Mar 11;15(5):2389-90
J:78237 Dobbins DE, et al., Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat. Biochem Biophys Res Commun. 2002 Jun 28;294(5):1114-20
J:79988 Van Wesenbeeck L, et al., The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14303-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:145880 Chen X, et al., Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18267-72