Sequence Detail

ID/Version

P06804 Q91VF3 O35853 Q62326 (UniProt | EBI)

Last sequence update: 1989-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tumor necrosis factor;AltName: Full=Cachectin;AltName: Full=TNF-alpha;AltName: Full=Tumor necrosis factor ligand superfamily member 2; Short=TNF-a;Contains: RecName: Full=Tumor necrosis factor, membrane form; AltName: Full=N-termin

Provider

SWISS-PROT

Sequence

Polypeptide 235 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tnf	tumor necrosis factor	370	145	4	59

Sequence references in MGI

J:9189 Shirai T, et al., Cloning and expression in Escherichia coli of the gene for mouse tumor necrosis factor. DNA. 1988 Apr;7(3):193-201
J:15363 Pennica D, et al., Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6060-4
J:20071 Fransen L, et al., Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression. Nucleic Acids Res. 1985 Jun 25;13(12):4417-29
J:24893 Semon D, et al., Nucleotide sequence of the murine TNF locus, including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes. Nucleic Acids Res. 1987 Nov 11;15(21):9083-4
J:29073 Ikegami H, et al., Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping. J Clin Invest. 1995 Oct;96(4):1936-42
J:30045 Caput D, et al., Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1670-4
J:40056 Iraqi F, et al., Cloning and sequencing of the tnfa genes of three inbred mouse strains. Immunogenetics. 1997;45(6):459-61
J:86796 Xie T, et al., Analysis of the gene-dense Major Histocompatibility Complex class III region and its comparison to mouse. Genome Res. 2003 Dec;13(12):2621-36
J:265598 Ando Y, et al., Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ialpha causes insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2015 Feb 27;290(9):5881-92
J:303193 Jeong E, et al., Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression. FASEB J. 2020 Sep;34(9):12894-12906