Sequence Detail

ID/Version

P06803 F6XDQ5 Q8CFN8 (UniProt | EBI)

Last sequence update: 2018-10-10
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase pim-1; EC=2.7.11.1;

Provider

SWISS-PROT

Sequence

Polypeptide 313 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pim1	proviral integration site 1	55	102	3	15

Sequence references in MGI

J:15259 Domen J, et al., Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells. Blood. 1993 Sep 1;82(5):1445-52
J:15285 Domen J, et al., Pim-1 levels determine the size of early B lymphoid compartments in bone marrow. J Exp Med. 1993 Nov 1;178(5):1665-73
J:15368 Selten G, et al., The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases. Cell. 1986 Aug 15;46(4):603-11
J:63919 Maita H, et al., PAP-1, a novel target protein of phosphorylation by pim-1 kinase. Eur J Biochem. 2000 Aug;267(16):5168-78
J:91592 Mikkers H, et al., Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol Cell Biol. 2004 Jul;24(13):6104-15
J:91967 Aho TL, et al., Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett. 2004 Jul 30;571(1-3):43-9
J:113704 Saris CJ, et al., The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J. 1991 Mar;10(3):655-64
J:152161 Grundler R, et al., Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med. 2009 Aug 31;206(9):1957-70
J:177147 Zhang Y, et al., Pim kinase-dependent inhibition of c-Myc degradation. Oncogene. 2008 Aug 14;27(35):4809-19
J:237490 Brunmeir R, et al., Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PLoS Genet. 2016 Dec;12(12):e1006474