Sequence Detail

ID/Version

P06332 (UniProt | EBI)

Last sequence update: 1988-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=T-cell surface glycoprotein CD4;AltName: Full=T-cell differentiation antigen L3T4;AltName: Full=T-cell surface antigen T4/Leu-3;AltName: CD_antigen=CD4;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 457 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd4	CD4 antigen	98	114	3	46

Sequence references in MGI

J:8578 Littman DR, et al., Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene. Nature. 1987 Jan 29-Feb 4;325(6103):453-5
J:32618 Tourvieille B, et al., Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain. Science. 1986 Oct 31;234(4776):610-4
J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
J:68957 Rahemtulla A, et al., Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature. 1991 Sep 12;353(6340):180-4
J:131790 Maekawa A, et al., Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC. J Immunol. 2006 Jun 1;176(11):6873-8
J:225416 Veillette A, et al., Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature. 1989 Mar 16;338(6212):257-9
J:225417 Veillette A, et al., The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell. 1988 Oct 21;55(2):301-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89