Sequence Detail

ID/Version

P05622 E9QPE2 (UniProt | EBI)

Last sequence update: 2019-07-03
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Platelet-derived growth factor receptor beta; Short=PDGF-R-beta; Short=PDGFR-beta; EC=2.7.10.1;AltName: Full=Beta platelet-derived growth factor receptor;AltName: Full=Beta-type platelet-derived growth factor receptor

Provider

SWISS-PROT

Sequence

Polypeptide 1098 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdgfrb	platelet derived growth factor receptor, beta polypeptide	133	158	3	38

Sequence references in MGI

J:8434 Yarden Y, et al., Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature. 1986 Sep 18-24;323(6085):226-32
J:20016 Soriano P, Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev. 1994 Aug 15;8(16):1888-96
J:86542 Tallquist MD, et al., Additive Effects of PDGF Receptor beta Signaling Pathways in Vascular Smooth Muscle Cell Development. PLoS Biol. 2003 Nov;1(2):288-99
J:88185 Persson C, et al., Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol. 2004 Mar;24(5):2190-201
J:89062 Plattner R, et al., Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Mol Cell Biol. 2004 Mar;24(6):2573-83
J:93973 Chiara F, et al., A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity. J Biol Chem. 2004 Oct 8;279(41):42516-27
J:130159 Van den Akker NM, et al., PDGF-B signaling is important for murine cardiac development: Its role in developing atrioventricular valves, coronaries, and cardiac innervation. Dev Dyn. 2008 Feb;237(2):494-503
J:153626 Zhou L, et al., LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One. 2009;4(9):e6922
J:155272 Mellgren AM, et al., Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res. 2008 Dec 5;103(12):1393-401
J:173602 Olson LE, et al., PDGFRbeta Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development. Dev Cell. 2011 Jun 14;20(6):815-26
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89