Sequence Detail

ID/Version

P05214 (UniProt | EBI)

Last sequence update: 1987-08-13
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tubulin alpha-3 chain; EC=3.6.5.- {ECO:0000250|UniProtKB:P68363};AltName: Full=Alpha-tubulin 3/7;AltName: Full=Alpha-tubulin isotype M-alpha-3/7;AltName: Full=Tubulin alpha-3/alpha-7 chain;Contains: RecName: Full=Detyrosinated tubul

Provider

SWISS-PROT

Sequence

Polypeptide 450 aa

Source

Organism mouse

See UniProt | EBI for source

Sequence references in MGI

J:25928 Villasante A, et al., Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol Cell Biol. 1986 Jul;6(7):2409-19
J:112743 Peris L, et al., Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends. J Cell Biol. 2006 Sep 11;174(6):839-49
J:150280 Rogowski K, et al., Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell. 2009 Jun 12;137(6):1076-87
J:150408 Peris L, et al., Motor-dependent microtubule disassembly driven by tubulin tyrosination. J Cell Biol. 2009 Jun 29;185(7):1159-66
J:201638 Bosch Grau M, et al., Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. J Cell Biol. 2013 Aug 5;202(3):441-51
J:227641 Kerr JP, et al., Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. Nat Commun. 2015;6:8526
J:241131 Janke C, et al., Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science. 2005 Jun 17;308(5729):1758-62
J:272424 Aillaud C, et al., Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Science. 2017 Dec 15;358(6369):1448-1453
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:300009 Gadadhar S, et al., Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Science. 2021 Jan 8;371(6525)
J:338030 Zhou L, et al., Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell. 2023 Jun 22;186(13):2897-2910.e19
J:352387 Tai L, et al., In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov. 2023 Nov 21;9(1):116