Sequence Detail

ID/Version

P05132 P05132 (UniProt | EBI)

Last sequence update: 2007-01-23 Last annotation update: 2012-11-28

Sequence description from provider

RecName: Full=cAMP-dependent protein kinase catalytic subunit alpha; Short=PKA C-alpha; EC=2.7.11.11;

Provider

SWISS-PROT

Sequence

Polypeptide 351 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prkaca	protein kinase, cAMP dependent, catalytic, alpha	53	9	6	6

Sequence references in MGI

J:9126 Chrivia JC, et al., Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase. J Biol Chem. 1988 Apr 25;263(12):5739-44
J:25675 Uhler MD, et al., Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1300-4
J:64713 Agustin JT, et al., The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative calpha mRNA expressed specifically in spermatogenic cells. Mol Biol Cell. 2000 Sep;11(9):3031-44
J:77110 Skalhegg BS, et al., Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. Mol Endocrinol. 2002 Mar;16(3):630-9
J:92616 Nolan MA, et al., Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13483-8
J:136048 Webb RJ, et al., Developmentally acquired PKA localisation in mouse oocytes and embryos. Dev Biol. 2008 May 1;317(1):36-45
J:152257 Baker MA, et al., Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation. Dev Biol. 2009 Sep 1;333(1):57-66
J:180569 Pirino G, et al., Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes. Cell Cycle. 2009 Feb 15;8(4):665-70