Sequence Detail

ID/Version

P05132 Q9JID0 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=cAMP-dependent protein kinase catalytic subunit alpha; Short=PKA C-alpha; EC=2.7.11.11 {ECO:0000269|PubMed:10805756, ECO:0000269|PubMed:19223768};

Provider

SWISS-PROT

Sequence

Polypeptide 351 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prkaca	protein kinase, cAMP dependent, catalytic, alpha	133	113	4	10

Sequence references in MGI

J:9126 Chrivia JC, et al., Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase. J Biol Chem. 1988 Apr 25;263(12):5739-44
J:25675 Uhler MD, et al., Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1300-4
J:64713 Agustin JT, et al., The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative calpha mRNA expressed specifically in spermatogenic cells. Mol Biol Cell. 2000 Sep;11(9):3031-44
J:77110 Skalhegg BS, et al., Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. Mol Endocrinol. 2002 Mar;16(3):630-9
J:92616 Nolan MA, et al., Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13483-8
J:136048 Webb RJ, et al., Developmentally acquired PKA localisation in mouse oocytes and embryos. Dev Biol. 2008 May 1;317(1):36-45
J:152257 Baker MA, et al., Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation. Dev Biol. 2009 Sep 1;333(1):57-66
J:175121 Huang W, et al., Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol. 2000 Jun;20(11):4149-58
J:180569 Pirino G, et al., Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes. Cell Cycle. 2009 Feb 15;8(4):665-70
J:236944 Stanger SJ, et al., A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation. FASEB J. 2016 Aug;30(8):2777-91
J:240313 Knighton DR, et al., Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science. 1991 Jul 26;253(5018):407-14
J:245387 Zhang P, et al., Structure and allostery of the PKA RIIbeta tetrameric holoenzyme. Science. 2012 Feb 10;335(6069):712-6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:341400 Arveseth CD, et al., Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PLoS Biol. 2021 Apr;19(4):e3001191