Sequence Detail

ID/Version

P04925 (UniProt | EBI)

Last sequence update: 1990-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Major prion protein; Short=PrP;AltName: Full=PrP27-30;AltName: Full=PrP33-35C;AltName: CD_antigen=CD230;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 254 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prnp	prion protein	158	120	4	99

Sequence references in MGI

J:7876 Chesebro B, et al., Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain. Nature. 1985 May 23-29;315(6017):331-3
J:8406 Locht C, et al., Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent. Proc Natl Acad Sci U S A. 1986 Sep;83(17):6372-6
J:8918 Westaway D, et al., Distinct prion proteins in short and long scrapie incubation period mice. Cell. 1987 Nov 20;51(4):651-62
J:19448 Collinge J, et al., Prion protein is necessary for normal synaptic function. Nature. 1994 Jul 28;370(6487):295-7
J:50880 Lee IY, et al., Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res. 1998 Oct;8(10):1022-37
J:72874 Spielhaupter C, et al., PrPC Directly Interacts with Proteins Involved in Signaling Pathways. J Biol Chem. 2001 Nov 30;276(48):44604-12
J:75094 Lorenz H, et al., Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases. J Biol Chem. 2002 Mar 8;277(10):8508-16
J:77633 Lledo PM, et al., Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2403-7
J:89232 Genoud N, et al., Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4198-203
J:91094 Paisley D, et al., Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. Am J Pathol. 2004 Jun;164(6):2279-88
J:107170 Steele AD, et al., Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3416-21
J:112079 Cheng F, et al., Copper-dependent co-internalization of the prion protein and glypican-1. J Neurochem. 2006 Sep;98(5):1445-57
J:145956 Lauren J, et al., Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature. 2009 Feb 26;457(7233):1128-32
J:151641 Singh A, et al., Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport. PLoS One. 2009;4(7):e6115
J:152730 Chakrabarti O, et al., Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. Cell. 2009 Jun 12;137(6):1136-47
J:158343 Bremer J, et al., Axonal prion protein is required for peripheral myelin maintenance. Nat Neurosci. 2010 Mar;13(3):310-8
J:163149 Pauly PC, et al., Copper stimulates endocytosis of the prion protein. J Biol Chem. 1998 Dec 11;273(50):33107-10
J:236616 Kuffer A, et al., The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature. 2016 Aug 25;536(7617):464-8
J:240271 Stevens DJ, et al., Early onset prion disease from octarepeat expansion correlates with copper binding properties. PLoS Pathog. 2009 Apr;5(4):e1000390
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89