Sequence Detail

ID/Version

P04441 O19452 (UniProt | EBI)

Last sequence update: 1991-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=H-2 class II histocompatibility antigen gamma chain {ECO:0000305};AltName: Full=Ia antigen-associated invariant chain; Short=Ii {ECO:0000303|PubMed:8977190}; Short=Ii chain {ECO:0000303|PubMed:8977190};AltName: Full=MHC class

Provider

SWISS-PROT

Sequence

Polypeptide 279 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	135	98	4	20

Sequence references in MGI

J:20082 Koch N, et al., Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin. EMBO J. 1987 Jun;6(6):1677-83
J:20103 Singer PA, et al., Structure of the murine Ia-associated invariant (Ii) chain as deduced from a cDNA clone. EMBO J. 1984 Apr;3(4):873-7
J:20112 Zhu L, et al., Complete sequence of the murine invariant chain (Ii) gene. Nucleic Acids Res. 1989 Jan 11;17(1):447-8
J:82880 Takaesu NT, et al., In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain. J Immunol. 1997 Jan 1;158(1):187-99
J:115604 Lennon-Dumenil AM, et al., The p41 isoform of invariant chain is a chaperone for cathepsin L. EMBO J. 2001 Aug 1;20(15):4055-64
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:271359 Fiebiger E, et al., Invariant chain controls the activity of extracellular cathepsin L. J Exp Med. 2002 Nov 4;196(9):1263-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297334 Bruchez A, et al., MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses. Science. 2020 Oct 9;370(6513):241-247