Sequence Detail

ID/Version

P04426 (UniProt | EBI)

Last sequence update: 1987-08-13
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Proto-oncogene Wnt-1;AltName: Full=Proto-oncogene Int-1 {ECO:0000303|PubMed:2202907, ECO:0000303|PubMed:6091914};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 370 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Wnt1	wingless-type MMTV integration site family, member 1	114	233	3	25

Sequence references in MGI

J:7608 van Ooyen A, et al., Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact. Cell. 1984 Nov;39(1):233-40
J:8400 Fung YK, et al., Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene [published erratum appears in Mol Cell Biol 1986 Apr;6(4):1362]. Mol Cell Biol. 1985 Dec;5(12):3337-44
J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
J:20267 Wilkinson DG, et al., Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell. 1987 Jul 3;50(1):79-88
J:63226 Tanaka K, et al., The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem. 2000 Jul;267(13):4300-11
J:67737 Thomas KR, et al., Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature. 1990 Aug 30;346(6287):847-50
J:93897 Lu W, et al., Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 2004 Oct 1;119(1):97-108
J:113117 Nam JS, et al., Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem. 2006 May 12;281(19):13247-57
J:154679 Fu J, et al., Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18598-603
J:168206 Liu Y, et al., Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nat Neurosci. 2005 Sep;8(9):1151-9
J:178219 Shackleford GM, et al., Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos. Cell. 1987 Jul 3;50(1):89-95
J:203641 Keupp K, et al., Mutations in WNT1 cause different forms of bone fragility. Am J Hum Genet. 2013 Apr 4;92(4):565-74