Sequence Detail

ID/Version

P04202 (UniProt | EBI)

Last sequence update: 1987-03-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transforming growth factor beta-1 proprotein;Contains: RecName: Full=Latency-associated peptide {ECO:0000250|UniProtKB:P01137}; Short=LAP;Contains: RecName: Full=Transforming growth factor beta-1 {ECO:0000250|UniProtKB:P01137};

Provider

SWISS-PROT

Sequence

Polypeptide 390 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tgfb1	transforming growth factor, beta 1	461	219	4	25

Sequence references in MGI

J:8238 Derynck R, et al., The murine transforming growth factor-beta precursor. J Biol Chem. 1986 Apr 5;261(10):4377-9
J:29931 Guron C, et al., Molecular organization of the gene encoding murine transforming growth factor beta 1. Gene. 1995 Nov 20;165(2):325-6
J:88555 Paliwal S, et al., P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2. Biochem Biophys Res Commun. 2004 Mar 19;315(4):1104-9
J:88556 Oka C, et al., HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Development. 2004 Mar;131(5):1041-53
J:91306 Tocharus J, et al., Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. Dev Growth Differ. 2004 Jun;46(3):257-74
J:136164 Zhou L, et al., TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 2008 May 8;453(7192):236-40
J:169435 Huser CA, et al., TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival. Cell Death Differ. 2010 Feb;17(2):304-15
J:180718 Saito M, et al., ADAMTSL6beta protein rescues fibrillin-1 microfibril disorder in a Marfan syndrome mouse model through the promotion of fibrillin-1 assembly. J Biol Chem. 2011 Nov 4;286(44):38602-13
J:190629 Niimori D, et al., Tsukushi controls the hair cycle by regulating TGF-beta1 signaling. Dev Biol. 2012 Dec 1;372(1):81-7
J:236570 Dubash AD, et al., Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. J Cell Biol. 2016 Feb 15;212(4):425-38
J:264027 Qin Y, et al., A Milieu Molecule for TGF-beta Required for Microglia Function in the Nervous System. Cell. 2018 Jun 28;174(1):156-171.e16
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:338226 Zhang Y, et al., Effects of transforming growth factor-beta1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level. Biochem Biophys Res Commun. 2021 Mar 19;545:105-111