Sequence Detail

ID/Version

P03958 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Adenosine deaminase; EC=3.5.4.4 {ECO:0000269|PubMed:10720488, ECO:0000269|PubMed:8634299, ECO:0000269|PubMed:8672487, ECO:0000269|PubMed:8942668, ECO:0000269|PubMed:9272950};AltName: Full=Adenosine aminohydrolase;

Provider

SWISS-PROT

Sequence

Polypeptide 352 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ada	adenosine deaminase	208	106	3	11

Sequence references in MGI

J:7937 Yeung CY, et al., Identification of functional murine adenosine deaminase cDNA clones by complementation in Escherichia coli. J Biol Chem. 1985 Aug 25;260(18):10299-307
J:10680 al-Ubaidi MR, et al., Structural and functional analysis of the murine adenosine deaminase gene. Genomics. 1990 Aug;7(4):476-85
J:25085 Wakamiya M, et al., Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3673-7
J:26731 Migchielsen AA, et al., Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Nat Genet. 1995 Jul;10(3):279-87
J:42444 Blackburn MR, et al., Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development. Development. 1997 Aug;124(16):3089-97
J:63493 Blackburn MR, et al., Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. J Exp Med. 2000 Jul 17;192(2):159-70
J:70827 Ehringer MA, et al., High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110603 Xu PA, et al., Function of murine adenosine deaminase in the gastrointestinal tract. Biochem Biophys Res Commun. 2000 Mar 24;269(3):749-57
J:110739 Apasov SG, et al., Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest. 2001 Jul;108(1):131-41
J:164794 Sideraki V, et al., Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry. 1996 Jun 18;35(24):7862-72
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:328859 Mohamedali KA, et al., Site-directed mutagenesis of active site glutamate-217 in mouse adenosine deaminase. Biochemistry. 1996 Feb 6;35(5):1672-80
J:328861 Sideraki V, et al., Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry. 1996 Nov 26;35(47):15019-28