Sequence Detail

ID/Version

P02463 Q3UHJ4 Q6GQS7 Q3UQV2 Q53X35 Q6PHB5 Q99LQ8 Q3UJE7 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Collagen alpha-1(IV) chain {ECO:0000305};Contains: RecName: Full=Arresten;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1669 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Col4a1	collagen, type IV, alpha 1	42	156	3	29

Sequence references in MGI

J:9215 Killen PD, et al., Structure of the amino-terminal portion of the murine alpha 1(IV) collagen chain and the corresponding region of the gene. J Biol Chem. 1988 Jun 25;263(18):8706-9
J:9494 Kaytes P, et al., Head-to-head arrangement of murine type IV collagen genes. J Biol Chem. 1988 Dec 25;263(36):19274-7
J:9702 Muthukumaran G, et al., The complete primary structure for the alpha 1-chain of mouse collagen IV. Differential evolution of collagen IV domains. J Biol Chem. 1989 Apr 15;264(11):6310-7
J:15730 Kurkinen M, et al., Extensive homology between the carboxyl-terminal peptides of mouse alpha 1(IV) and alpha 2(IV) collagen. J Biol Chem. 1987 Jun 25;262(18):8496-9
J:28556 Killen PD, et al., Characterization of the promoter for the alpha 1 (IV) collagen gene. DNA sequences within the first intron enhance transcription. J Biol Chem. 1988 Sep 5;263(25):12310-4
J:29569 Burbelo PD, et al., Alpha 1(IV) and alpha 2(IV) collagen genes are regulated by a bidirectional promoter and a shared enhancer. Proc Natl Acad Sci U S A. 1988 Dec;85(24):9679-82
J:32370 Sakurai Y, et al., Alpha 1 type IV collagen gene evolved differently from fibrillar collagen genes. J Biol Chem. 1986 May 25;261(15):6654-7
J:51552 Oberbaumer I, et al., Amino acid sequence of the non-collagenous globular domain (NC1) of the alpha 1(IV) chain of basement membrane collagen as derived from complementary DNA. Eur J Biochem. 1985 Mar 1;147(2):217-24
J:98572 Gould DB, et al., Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly. Science. 2005 May 20;308(5725):1167-71
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:121136 Kobayashi N, et al., A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization. J Biol Chem. 2007 Apr 20;282(16):11805-16
J:206377 Pokidysheva E, et al., Biological role of prolyl 3-hydroxylation in type IV collagen. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):161-6
J:220554 Hudson DM, et al., Post-translationally Abnormal Collagens of Prolyl 3-Hydroxylase-2 Null Mice Offer a Pathobiological Mechanism for the High Myopia Linked to Human LEPREL1 Mutations. J Biol Chem. 2015 Mar 27;290(13):8613-22
J:255314 Bhave G, et al., The sulfilimine cross-link of collagen IV contributes to kidney tubular basement membrane stiffness. Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F596-F602
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:320269 Bhave G, et al., Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis. Nat Chem Biol. 2012 Sep;8(9):784-90