Sequence Detail

ID/Version

P02340 Q9QUP3 (UniProt | EBI)

Last sequence update: 2018-10-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cellular tumor antigen p53;AltName: Full=Tumor suppressor p53;

Provider

SWISS-PROT

Sequence

Polypeptide 390 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trp53	transformation related protein 53	502	241	3	367

Sequence references in MGI

J:2001 Burns PA, et al., Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice. Oncogene. 1991 Dec;6(12):2363-9
J:7256 Zakut-Houri R, et al., A single gene and a pseudogene for the cellular tumour antigen p53. Nature. 1983 Dec 8-14;306(5943):594-7
J:7523 Jenkins JR, et al., Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53. Nucleic Acids Res. 1984 Jul 25;12(14):5609-26
J:7611 Bienz B, et al., Analysis of the gene coding for the murine cellular tumour antigen p53. EMBO J. 1984 Sep;3(9):2179-83
J:34250 Arai N, et al., Immunologically distinct p53 molecules generated by alternative splicing. Mol Cell Biol. 1986 Sep;6(9):3232-9
J:72328 Luo J, et al., Negative Control of p53 by Sir2alpha Promotes Cell Survival under Stress. Cell. 2001 Oct 19;107(2):137-48
J:91346 Lim SK, et al., Identification and characterization of murine mHAUSP encoding a deubiquitinating enzyme that regulates the status of p53 ubiquitination. Int J Oncol. 2004 Feb;24(2):357-64
J:94782 Rui Y, et al., Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 2004 Nov 24;23(23):4583-94
J:99823 Kondo S, et al., Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5431-6
J:114013 Tsuji K, et al., Differential effect of ik3-1/cables on p53- and p73-induced cell death. J Biol Chem. 2002 Jan 25;277(4):2951-7
J:114836 Ho WC, et al., Structure of the p53 core domain dimer bound to DNA. J Biol Chem. 2006 Jul 21;281(29):20494-502
J:117893 Sun P, et al., PRAK is essential for ras-induced senescence and tumor suppression. Cell. 2007 Jan 26;128(2):295-308
J:127713 Arai S, et al., Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9. FEBS Lett. 2007 Dec 11;581(29):5649-57
J:146960 Nishiyama M, et al., CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol. 2009 Feb;11(2):172-82
J:150816 Allton K, et al., Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11612-6
J:167935 Huarte M, et al., A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 2010 Aug 6;142(3):409-19
J:169789 Bernardi R, et al., PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol. 2004 Jul;6(7):665-72
J:186254 Vaseva AV, et al., p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis. Cell. 2012 Jun 22;149(7):1536-48
J:200408 Das S, et al., Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell. 2007 Aug 24;130(4):624-37
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:217260 Miki T, et al., p53 regulates Period2 expression and the circadian clock. Nat Commun. 2013;4:2444
J:222111 Qin B, et al., DBC1 functions as a tumor suppressor by regulating p53 stability. Cell Rep. 2015 Mar 3;10(8):1324-34
J:265621 Yan S, et al., FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage. Oncogene. 2014 Nov 20;33(47):5424-33
J:300494 Li M, et al., Aldolase B suppresses hepatocellar carcinogenesis by inhibiting G6PD and pentose phoshate pathways. Nature Cancer. 2020 Jul;1:735-747