Sequence Detail

ID/Version

P01575 (UniProt | EBI)

Last sequence update: 1986-07-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interferon beta {ECO:0000303|PubMed:2726460, ECO:0000303|PubMed:6688252}; Short=IFN-beta {ECO:0000303|PubMed:2726460};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 182 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ifnb1	interferon beta 1, fibroblast	64	103	4	22

Sequence references in MGI

J:7139 Higashi Y, et al., Structure and expression of a cloned cDNA for mouse interferon-beta. J Biol Chem. 1983 Aug 10;258(15):9522-9
J:9811 Kuga T, et al., Nucleotide sequence of the mouse interferon-beta gene. Nucleic Acids Res. 1989 Apr 25;17(8):3291
J:26747 Vodjdani G, et al., Structure and characterization of a murine chromosomal fragment containing the interferon beta gene. J Mol Biol. 1988 Nov 20;204(2):221-31
J:61048 Deonarain R, et al., Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon. J Virol. 2000 Apr;74(7):3404-9
J:83021 Teige I, et al., IFN-beta Gene Deletion Leads to Augmented and Chronic Demyelinating Experimental Autoimmune Encephalomyelitis. J Immunol. 2003 May 1;170(9):4776-84
J:86527 Deonarain R, et al., Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13453-8
J:208239 de Weerd NA, et al., Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1. Nat Immunol. 2013 Sep;14(9):901-7
J:226090 Ejlerskov P, et al., Lack of Neuronal IFN-beta-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia. Cell. 2015 Oct 8;163(2):324-39