Sequence Detail

ID/Version

P00520 Q61254 Q61253 P97896 Q6PCM5 Q61257 Q8C1X4 Q61258 Q61255 Q61259 Q61256 Q61261 Q61260 Q61252 (UniProt | EBI)

Last sequence update: 2005-02-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosine-protein kinase ABL1; EC=2.7.10.2 {ECO:0000269|PubMed:10988075, ECO:0000269|PubMed:12748290, ECO:0000269|PubMed:19878872, ECO:0000269|PubMed:20072125};AltName: Full=Abelson murine leukemia viral oncogene homolog 1;AltName: Fu

Provider

SWISS-PROT

Sequence

Polypeptide 1123 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	312	112	3	59

Sequence references in MGI

J:7292 Wang JY, et al., The mouse c-abl locus: molecular cloning and characterization. Cell. 1984 Feb;36(2):349-56
J:9153 Bernards A, et al., Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing. Oncogene. 1988 Apr;2(4):297-304
J:14644 Schwartzberg PL, et al., Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations. Cell. 1991 Jun 28;65(7):1165-75
J:40703 Oppi C, et al., Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation. Proc Natl Acad Sci U S A. 1987 Dec;84(23):8200-4
J:63117 Zukerberg LR, et al., Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron. 2000 Jun;26(3):633-46
J:72875 Tybulewicz VL, et al., Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell. 1991 Jun 28;65(7):1153-63
J:89062 Plattner R, et al., Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Mol Cell Biol. 2004 Mar;24(6):2573-83
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116250 Tanis KQ, et al., Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Mol Cell Biol. 2003 Jun;23(11):3884-96
J:116356 Kain KH, et al., Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes. J Biol Chem. 2001 May 11;276(19):16185-92
J:116366 Taagepera S, et al., Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7457-62
J:116399 Kharbanda S, et al., Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature. 1997 Apr 17;386(6626):732-5
J:155307 Baruzzi A, et al., c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010 Jan 4;584(1):15-21
J:175086 Chen A, et al., c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4+ T-Cell Differentiation and Allergic Lung Inflammation. Mol Cell Biol. 2011 Aug;31(16):3445-56
J:200513 Cong F, et al., Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation. Mol Cell. 2000 Dec;6(6):1413-23
J:230384 Zambrano N, et al., The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. J Biol Chem. 2001 Jun 8;276(23):19787-92
J:259787 Gu JJ, et al., Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. Sci Signal. 2012 Jul 17;5(233):ra51