Sequence Detail

ID/Version

O89094 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Caspase-14; Short=CASP-14; EC=3.4.22.-;AltName: Full=Mini-ICE; Short=MICE;Contains: RecName: Full=Caspase-14 subunit p17, mature form;Contains: RecName: Full=Caspase-14 subunit p10, mature form;Contains: RecName: F

Provider

SWISS-PROT

Sequence

Polypeptide 257 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Casp14	caspase 14	34	104	2	6

Sequence references in MGI

J:50860 Ahmad M, et al., Identification and characterization of murine caspase-14, a new member of the caspase family. Cancer Res. 1998 Nov 15;58(22):5201-5
J:50861 Hu S, et al., Caspase-14 is a novel developmentally regulated protease. J Biol Chem. 1998 Nov 6;273(45):29648-53
J:74158 Kuechle MK, et al., Caspase-14, a keratinocyte specific caspase: mRNA splice variants and expression pattern in embryonic and adult mouse. Cell Death Differ. 2001 Aug;8(8):868-70
J:129490 Denecker G, et al., Caspase-14 protects against epidermal UVB photodamage and water loss. Nat Cell Biol. 2007 Jun;9(6):666-74
J:130935 Demerjian M, et al., Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2. Am J Pathol. 2008 Jan;172(1):86-97
J:180909 Hoste E, et al., Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. J Invest Dermatol. 2011 Nov;131(11):2233-41
J:216017 Yamamoto-Tanaka M, et al., Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation. J Biol Chem. 2014 Jul 18;289(29):20026-38