Sequence Detail

ID/Version

O88942 O70345 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear factor of activated T-cells, cytoplasmic 1; Short=NF-ATc1; Short=NFATc1;AltName: Full=NFAT transcription complex cytosolic component; Short=NF-ATc; Short=NFATc {ECO:0000303|PubMed:9388475};

Provider

SWISS-PROT

Sequence

Polypeptide 717 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nfatc1	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	89	135	3	27

Sequence references in MGI

J:44350 Pan S, et al., Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc. Biochem Biophys Res Commun. 1997 Nov 17;240(2):314-23
J:119549 Yang XY, et al., Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition. Dev Biol. 2007 Mar 15;303(2):825-37
J:141917 Cante-Barrett K, et al., Selective role of NFATc3 in positive selection of thymocytes. J Immunol. 2007 Jul 1;179(1):103-10
J:159586 Pena JA, et al., Loss of calcineurin Aalpha alters keratinocyte survival and differentiation. J Invest Dermatol. 2010 Jan;130(1):135-40
J:169854 Reddy RN, et al., Rescue of Calcineurin Aalpha(-/-) Mice Reveals a Novel Role for the alpha Isoform in the Salivary Gland. Am J Pathol. 2011 Apr;178(4):1605-13
J:175305 Lee HL, et al., High extracellular calcium-induced NFATc3 regulates the expression of receptor activator of NF-kappaB ligand in osteoblasts. Bone. 2011 Aug;49(2):242-9
J:228311 Decker CE, et al., Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15654-9
J:235251 Tiedemann K, et al., Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism. J Cell Sci. 2013 Sep 15;126(Pt 18):4187-94
J:242765 Murakami A, et al., Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling. J Biol Chem. 2017 May 12;292(19):7994-8006
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297319 Kogawa M, et al., The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation. J Biol Chem. 2013 Oct 25;288(43):31299-312
J:303193 Jeong E, et al., Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression. FASEB J. 2020 Sep;34(9):12894-12906
J:320150 Sun L, et al., Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts. Am J Physiol Renal Physiol. 2007 Jan;292(1):F285-91
J:334006 Choi HK, et al., Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. Cell Res. 2013 Apr;23(4):524-36
J:343111 Ranjan R, et al., The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis. J Innate Immun. 2014;6(6):754-64