Sequence Detail

ID/Version

O88904 Q9QZR3 Q9QUQ8 A6H5Z7 Q80TV5 Q9WVN7 (UniProt | EBI)

Last sequence update: 2005-03-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Homeodomain-interacting protein kinase 1; EC=2.7.11.1;AltName: Full=Nuclear body-associated kinase 2;AltName: Full=Protein kinase Myak;

Provider

SWISS-PROT

Sequence

Polypeptide 1210 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hipk1	homeodomain interacting protein kinase 1	68	99	4	26

Sequence references in MGI

J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
J:60697 Shang E, et al., Murine Myak, a member of a family of yeast YAK1-related genes, is highly expressed in hormonally modulated epithelia in the reproductive system and in the embryonic central nervous system. Mol Reprod Dev. 2000 Apr;55(4):372-8
J:81640 Ecsedy JA, et al., Homeodomain-interacting protein kinase 1 modulates daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol. 2003 Feb;23(3):950-60
J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:99823 Kondo S, et al., Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5431-6
J:112873 Aikawa Y, et al., Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J. 2006 Sep 6;25(17):3955-65
J:150995 Li X, et al., SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell Death Differ. 2008 Apr;15(4):739-50
J:162323 Inoue T, et al., Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 2010 Jul 16;584(14):3233-8