Sequence Detail

ID/Version

O88898 O88897 O89097 Q9QWZ0 Q8C826 O88899 Q9QWY9 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Tumor protein 63; Short=p63;AltName: Full=Transformation-related protein 63; Short=TP63;AltName: Full=Tumor protein p73-like; Short=p73L;

Provider

SWISS-PROT

Sequence

Polypeptide 680 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trp63	transformation related protein 63	148	232	3	39

Sequence references in MGI

J:45977 Senoo M, et al., A second p53-related protein, p73L, with high homology to p73 [published erratum appears in Biochem Biophys Res Commun 1998 Sep 18;250(2):536]. Biochem Biophys Res Commun. 1998 Jul 30;248(3):603-7
J:50106 Yang A, et al., p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998 Sep;2(3):305-16
J:54636 Mills AA, et al., p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 1999 Apr 22;398(6729):708-13
J:54637 Yang A, et al., p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999 Apr 22;398(6729):714-8
J:77565 Flores ER, et al., p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature. 2002 Apr 4;416(6880):560-4
J:87781 Koster MI, et al., p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 2004 Jan 15;18(2):126-31
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:183160 Mitchell K, et al., Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus. Am J Hum Genet. 2012 Jan 13;90(1):69-75
J:297664 Simonson L, et al., Keratin 13 deficiency causes white sponge nevus in mice. Dev Biol. 2020 Dec 1;468(1-2):146-153
J:333827 Huang C, et al., TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis. J Clin Invest. 2023 Mar 1;133(5)