Sequence Detail

ID/Version

O88736 Q921L1 Q8K5C9 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 {ECO:0000305};AltName: Full=17-beta-hydroxysteroid dehydrogenase 7; Short=17-beta-HSD 7;AltName: Full=3-keto-steroid reductase; EC=1.1.1.270 {ECO:0000269|PubMed:

Provider

SWISS-PROT

Sequence

Polypeptide 334 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hsd17b7	hydroxysteroid (17-beta) dehydrogenase 7	29	101	3	9

Sequence references in MGI

J:48295 Nokelainen P, et al., Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Mol Endocrinol. 1998 Jul;12(7):1048-59
J:83553 Torn S, et al., Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7. Biochem Biophys Res Commun. 2003 May 23;305(1):37-45
J:85283 Marijanovic Z, et al., Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Mol Endocrinol. 2003 Sep;17(9):1715-25
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:140055 Shehu A, et al., Prolactin receptor-associated protein/17beta-hydroxysteroid dehydrogenase type 7 gene (Hsd17b7) plays a crucial role in embryonic development and fetal survival. Mol Endocrinol. 2008 Oct;22(10):2268-77
J:170013 Taramino S, et al., Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. Biochim Biophys Acta. 2010 Nov;1801(11):1232-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89