Sequence Detail

ID/Version

O88712 Q3TDL5 Q9QYG2 Q91YX3 Q3TUM5 Q3TAT1 Q91WI6 (UniProt | EBI)

Last sequence update: 2007-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=C-terminal-binding protein 1; Short=CtBP1; EC=1.1.1.-;

Provider

SWISS-PROT

Sequence

Polypeptide 441 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ctbp1	C-terminal binding protein 1	71	109	4	20

Sequence references in MGI

J:58553 Furusawa T, et al., Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. Mol Cell Biol. 1999 Dec;19(12):8581-90
J:61746 Criqui-Filipe P, et al., Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. EMBO J. 1999 Jun 15;18(12):3392-403
J:67665 Zhang CL, et al., Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001 Jan 5;276(1):35-9
J:86139 Zhang Q, et al., Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell. 2003 Oct 17;115(2):177-86
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102102 Li S, et al., Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol. 2004 Jan;24(2):809-22
J:104117 Kim SC, et al., Kruppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1). Nucleic Acids Res. 2005;33(21):6805-15
J:114142 Christian M, et al., Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. J Biol Chem. 2004 Apr 9;279(15):15645-51
J:114884 Ueda J, et al., Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. J Biol Chem. 2006 Jul 21;281(29):20120-8
J:151916 Pan F, et al., Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science. 2009 Aug 28;325(5944):1142-6
J:153416 Kajimura S, et al., Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15;22(10):1397-409
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89