Sequence Detail

ID/Version

O88696 Q3TI13 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=ATP-dependent Clp protease proteolytic subunit, mitochondrial; EC=3.4.21.92 {ECO:0000250|UniProtKB:Q16740};AltName: Full=Caseinolytic mitochondrial matrix peptidase proteolytic subunit {ECO:0000312|MGI:MGI:1858213};AltName: Full=Endo

Provider

SWISS-PROT

Sequence

Polypeptide 272 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clpp	caseinolytic mitochondrial matrix peptidase proteolytic subunit	41	100	3	19

Sequence references in MGI

J:61064 Andresen BS, et al., Characterization of mouse Clpp protease cDNA, gene, and protein. Mamm Genome. 2000 Apr;11(4):275-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:203140 Gispert S, et al., Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors. Hum Mol Genet. 2013 Dec 15;22(24):4871-87
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89