Sequence Detail

ID/Version

O88597 Q99J03 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Beclin-1;AltName: Full=Coiled-coil myosin-like BCL2-interacting protein;Contains: RecName: Full=Beclin-1-C 35 kDa {ECO:0000303|PubMed:21364619};Contains: RecName: Full=Beclin-1-C 37 kDa {ECO:0000303|PubMed:21364619};

Provider

SWISS-PROT

Sequence

Polypeptide 448 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Becn1	beclin 1, autophagy related	139	112	3	19

Sequence references in MGI

J:64816 Liang XH, et al., Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96
J:78719 Yue Z, et al., A Novel Protein Complex Linking the delta2 Glutamate Receptor and Autophagy. Implications for Neurodegeneration in Lurcher Mice. Neuron. 2002 Aug 29;35(5):921-933
J:86982 Yue Z, et al., Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15077-82
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122795 Maria Fimia G, et al., Ambra1 regulates autophagy and development of the nervous system. Nature. 2007 Jun 28;447(7148):1121-5
J:166673 Dou Z, et al., The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. J Cell Biol. 2010 Nov 15;191(4):827-43
J:185616 Ma C, et al., Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J Biol Chem. 2012 May 25;287(22):18359-65
J:219056 Kim J, et al., Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell. 2013 Jan 17;152(1-2):290-303
J:219088 Zhong Y, et al., Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol. 2009 Apr;11(4):468-76
J:220512 Tang D, et al., Endogenous HMGB1 regulates autophagy. J Cell Biol. 2010 Sep 6;190(5):881-92
J:232323 McKnight NC, et al., Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. PLoS Genet. 2014 Oct;10(10):e1004626
J:252513 Ashkenazi A, et al., Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature. 2017 May 4;545(7652):108-111
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:308934 Lei Y, et al., Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility. Dev Cell. 2021 Aug 23;56(16):2313-2328.e7