Sequence Detail

ID/Version

O88572 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Low-density lipoprotein receptor-related protein 6; Short=LRP-6;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1613 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lrp6	low density lipoprotein receptor-related protein 6	172	118	3	32

Sequence references in MGI

J:49065 Brown SD, et al., Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. Biochem Biophys Res Commun. 1998 Jul 30;248(3):879-88
J:82316 Hsieh JC, et al., Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell. 2003 Feb 7;112(3):355-67
J:91055 Kelly OG, et al., The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development. 2004 Jun;131(12):2803-15
J:93008 Kokubu C, et al., Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development. 2004 Nov;131(21):5469-80
J:113117 Nam JS, et al., Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem. 2006 May 12;281(19):13247-57
J:126796 Khan Z, et al., Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor. Mol Cell Biol. 2007 Oct;27(20):7291-301
J:153413 Kubota T, et al., Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd. J Bone Miner Res. 2008 Oct;23(10):1661-71
J:154861 Miyake A, et al., Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. Biochem Biophys Res Commun. 2009 Dec 18;390(3):1051-5
J:163129 Tezuka N, et al., GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway. Biochem Biophys Res Commun. 2007 May 11;356(3):648-54
J:273584 Sakaguchi N, et al., Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons. Neurosci Res. 2003 Feb;45(2):219-24
J:274568 Choi JH, et al., LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. Science. 2019 May 10;364(6440)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89