Sequence Detail

ID/Version

O88552 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Claudin-2 {ECO:0000303|PubMed:23677799};

Provider

SWISS-PROT

Sequence

Polypeptide 230 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cldn2	claudin 2	41	116	3	8

Sequence references in MGI

J:48635 Furuse M, et al., Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998 Jun 29;141(7):1539-50
J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
J:94758 Furuse M, et al., Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol. 1999 Nov 15;147(4):891-903
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113790 Kubota K, et al., Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr Biol. 1999 Sep 23;9(18):1035-8
J:237065 Pei L, et al., Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest. 2016 Jul 01;126(7):2509-18
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:310461 Matsumoto K, et al., Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice. Gastroenterology. 2014 Nov;147(5):1134-45.e10
J:313856 Curry JN, et al., Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease. J Clin Invest. 2020 Apr 1;130(4):1948-1960
J:330151 Wada M, et al., Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in gut and leads to death from malnutrition. Gastroenterology. 2013 Feb;144(2):369-380
J:330152 Tsai PY, et al., IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host Microbe. 2017 Jun 14;21(6):671-681.e4
J:345034 Amasheh S, et al., Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci. 2002 Dec 15;115(Pt 24):4969-76
J:352568 Yu AS, et al., Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J Gen Physiol. 2009 Jan;133(1):111-27