Sequence Detail

ID/Version

O88508 Q8CJ60 Q922J0 Q9CSE1 Q3UH24 Q3TZK8 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=DNA (cytosine-5)-methyltransferase 3A; Short=Dnmt3a; EC=2.1.1.37 {ECO:0000269|PubMed:11399089, ECO:0000269|PubMed:9662389};AltName: Full=Cysteine methyltransferase DNMT3A {ECO:0000305}; EC=2.1.1.- {ECO:0000269|PubMed:

Provider

SWISS-PROT

Sequence

Polypeptide 908 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dnmt3a	DNA methyltransferase 3A	87	153	4	100

Sequence references in MGI

J:48528 Okano M, et al., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet. 1998 Jul;19(3):219-20
J:58298 Okano M, et al., DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999 Oct 29;99(3):247-57
J:72444 Gowher H, et al., Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites. J Mol Biol. 2001 Jun 22;309(5):1201-8
J:79451 Chen T, et al., A novel dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem. 2002 Oct 11;277(41):38746-54
J:91108 Kaneda M, et al., Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature. 2004 Jun 24;429(6994):900-3
J:93321 Chen T, et al., The PWWP Domain of Dnmt3a and Dnmt3b Is Required for Directing DNA Methylation to the Major Satellite Repeats at Pericentric Heterochromatin. Mol Cell Biol. 2004 Nov;24(20):9048-58
J:98706 Gowher H, et al., Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. J Biol Chem. 2005 Apr 8;280(14):13341-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110326 Gowher H, et al., Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase. J Mol Biol. 2006 Mar 31;357(3):928-41
J:150923 Ling Y, et al., Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 2004;32(2):598-610
J:150927 Gowher H, et al., Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases. J Biol Chem. 2002 Jun 7;277(23):20409-14
J:161259 Meilinger D, et al., Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep. 2009 Nov;10(11):1259-64
J:168955 Takeshima H, et al., Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1. J Mol Biol. 2008 Nov 21;383(4):810-21
J:193011 Siddique AN, et al., Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. FEBS J. 2011 Jun;278(12):2055-63
J:245372 Jia D, et al., Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature. 2007 Sep 13;449(7159):248-51
J:291356 Heyn P, et al., Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions. Nat Genet. 2019 Jan;51(1):96-105
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:295943 Zoch A, et al., SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation. Nature. 2020 Aug;584(7822):635-639
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87