Sequence Detail

ID/Version

O88343 Q8BUG0 Q8QZR9 Q9R1C4 Q3USE4 (UniProt | EBI)

Last sequence update: 2005-12-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Electrogenic sodium bicarbonate cotransporter 1; Short=Sodium bicarbonate cotransporter;AltName: Full=Na(+)/HCO3(-) cotransporter;AltName: Full=Solute carrier family 4 member 4;

Provider

SWISS-PROT

Sequence

Polypeptide 1079 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc4a4	solute carrier family 4 (anion exchanger), member 4	57	102	4	9

Sequence references in MGI

J:62645 Abuladze N, et al., Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem. 1998 Jul 10;273(28):17689-95
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111036 Shirakabe K, et al., IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9542-7
J:144738 Yang D, et al., IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest. 2009 Jan;119(1):193-202
J:172037 Yang D, et al., IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011 Mar 1;121(3):956-65
J:198913 Alvarez BV, et al., Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. Biochemistry. 2003 Oct 28;42(42):12321-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:326232 Praetorius J, et al., Molecular and functional evidence for electrogenic and electroneutral Na(+)-HCO(3)(-) cotransporters in murine duodenum. Am J Physiol Gastrointest Liver Physiol. 2001 Mar;280(3):G332-43
J:326233 Bachmann O, et al., cAMP-mediated regulation of murine intestinal/pancreatic Na+/HCO3- cotransporter subtype pNBC1. Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G37-45
J:326271 Pushkin A, et al., Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells. J Physiol. 2004 Aug 15;559(Pt 1):55-65