Sequence Detail

ID/Version

O70496 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=H(+)/Cl(-) exchange transporter 7;AltName: Full=Chloride channel 7 alpha subunit;AltName: Full=Chloride channel protein 7; Short=ClC-7;

Provider

SWISS-PROT

Sequence

Polypeptide 803 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clcn7	chloride channel, voltage-sensitive 7	13	101	3	23

Sequence references in MGI

J:67273 Kornak U, et al., Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell. 2001 Jan 26;104(2):205-15
J:106978 Lange PF, et al., ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function. Nature. 2006 Mar 9;440(7081):220-3
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:155176 Wartosch L, et al., Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7. FASEB J. 2009 Dec;23(12):4056-68
J:282832 Nicoli ER, et al., Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification. Am J Hum Genet. 2019 Jun 6;104(6):1127-1138