Sequence Detail

ID/Version

O70491 Q6DIA8 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Receptor for retinol uptake STRA6;AltName: Full=Retinoic acid-responsive protein;AltName: Full=Retinol-binding protein receptor STRA6;AltName: Full=Stimulated by retinoic acid gene 6 protein {ECO:0000303|PubMed:9203140};

Provider

SWISS-PROT

Sequence

Polypeptide 670 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Stra6	stimulated by retinoic acid gene 6	58	113	3	24

Sequence references in MGI

J:28290 Taneja R, et al., Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7854-8
J:35169 Chazaud C, et al., Restricted expression of a novel retinoic acid responsive gene during limb bud dorsoventral patterning and endochondral ossification. Dev Genet. 1996;19(1):66-73
J:40904 Bouillet P, et al., Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein. Mech Dev. 1997 May;63(2):173-86
J:61450 Sapin V, et al., Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation. Mech Dev. 2000 Apr;92(2):295-9
J:170821 Berry DC, et al., Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4340-5
J:196841 Ruiz A, et al., Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Invest Ophthalmol Vis Sci. 2012;53(6):3027-39
J:203449 Berry DC, et al., The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem. 2013 Aug 23;288(34):24528-39
J:214659 Amengual J, et al., STRA6 is critical for cellular vitamin A uptake and homeostasis. Hum Mol Genet. 2014 Oct 15;23(20):5402-17