Sequence Detail

ID/Version

O70481 Q792M3 A2AQ54 Q5BKR8 Q8C5K3 Q8BN40 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase UBR1 {ECO:0000305}; EC=2.3.2.27 {ECO:0000269|PubMed:14585983, ECO:0000269|PubMed:19008229};AltName: Full=N-recognin-1;AltName: Full=Ubiquitin-protein ligase E3-alpha-1;AltName: Full=Ubiquitin-protein ligas

Provider

SWISS-PROT

Sequence

Polypeptide 1757 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ubr1	ubiquitin protein ligase E3 component n-recognin 1	45	103	3	15

Sequence references in MGI

J:48738 Kwon YT, et al., The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7898-903
J:72859 Kwon YT, et al., Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3alpha) of the N-End Rule Pathway. Mol Cell Biol. 2001 Dec;21(23):8007-21
J:86438 Kwon YT, et al., Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol Cell Biol. 2003 Nov;23(22):8255-71
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105229 Zenker M, et al., Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet. 2005 Dec;37(12):1345-50
J:109036 An JY, et al., Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6212-7
J:145887 Tasaki T, et al., The substrate recognition domains of the N-end rule pathway. J Biol Chem. 2009 Jan 16;284(3):1884-95
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89