Sequence Detail

ID/Version

O70405 Q6PGB2 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase ULK1; EC=2.7.11.1 {ECO:0000305|PubMed:22539723, ECO:0000305|PubMed:25723488};AltName: Full=Serine/threonine-protein kinase Unc51.1;AltName: Full=Unc-51-like kinase 1;

Provider

SWISS-PROT

Sequence

Polypeptide 1051 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ulk1	unc-51 like kinase 1	115	106	4	44

Sequence references in MGI

J:47612 Yan J, et al., Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun. 1998 May 8;246(1):222-7
J:59129 Tomoda T, et al., A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons. Neuron. 1999 Dec;24(4):833-46
J:149848 Ganley IG, et al., ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem. 2009 May 1;284(18):12297-305
J:167980 Egan DF, et al., Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011 Jan 28;331(6016):456-61
J:175316 Kim J, et al., AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011 Feb;13(2):132-41
J:183987 Lin SY, et al., GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science. 2012 Apr 27;336(6080):477-81
J:207232 Seldin MM, et al., Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 2013 Dec 13;288(50):36073-82
J:213953 Ro SH, et al., Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 2014 Sep;281(17):3816-27
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343213 Lim J, et al., Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet. 2015;11(2):e1004987