Sequence Detail

ID/Version

O70374 Q30BK8 B2RRH8 Q6P288 (UniProt | EBI)

Last sequence update: 2008-01-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein CBFA2T2;AltName: Full=MTG8-like protein;AltName: Full=MTG8-related protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 594 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cbfa2t2	CBFA2/RUNX1 translocation partner 2	35	103	3	194

Sequence references in MGI

J:50334 Calabi F, et al., CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Genomics. 1998 Sep 15;52(3):332-41
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102172 Amann JM, et al., Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol. 2005 Nov;25(21):9576-85
J:150704 Alishahi A, et al., Regional expression of MTG genes in the developing mouse central nervous system. Dev Dyn. 2009 Jul 17;238(8):2095-2102
J:155127 Cai Y, et al., Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors. Biochem Biophys Res Commun. 2009 Dec 11;390(2):295-301
J:169373 Barrett CW, et al., MTGR1 Is Required for Tumorigenesis in the Murine AOM/DSS Colitis-Associated Carcinoma Model. Cancer Res. 2011 Feb 15;71(4):1302-12
J:219649 Parang B, et al., The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J. 2015 Mar;29(3):786-95
J:233634 Nady N, et al., ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation. Elife. 2015;4:e10150
J:233954 Tu S, et al., Co-repressor CBFA2T2 regulates pluripotency and germline development. Nature. 2016 Jun 16;534(7607):387-90