Sequence Detail

ID/Version

O70361 A2A894 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Period circadian protein homolog 3; Short=mPER3;AltName: Full=Circadian clock protein PERIOD 3;

Provider

SWISS-PROT

Sequence

Polypeptide 1113 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Per3	period circadian clock 3	39	101	3	13

Sequence references in MGI

J:48281 Zylka MJ, et al., Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron. 1998 Jun;20(6):1103-10
J:69626 Bae K, et al., Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock. Neuron. 2001 May;30(2):525-36
J:73173 Vielhaber EL, et al., Nuclear Export of Mammalian PERIOD Proteins. J Biol Chem. 2001 Dec 7;276(49):45921-7
J:87576 Lee C, et al., Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan;24(2):584-94
J:178770 Hasan S, et al., Altered sleep and behavioral activity phenotypes in PER3-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2011 Dec;301(6):R1821-30
J:181980 Kucera N, et al., Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3311-6
J:209489 Shirogane T, et al., SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J Biol Chem. 2005 Jul 22;280(29):26863-72
J:229233 Zhang L, et al., A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1536-44