Sequence Detail

ID/Version

O70302 Q4V9X2 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Lipid transferase CIDEA {ECO:0000305};AltName: Full=Cell death activator CIDE-A {ECO:0000303|PubMed:9564035};AltName: Full=Cell death-inducing DFFA-like effector A {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 217 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cidea	cell death-inducing DNA fragmentation factor, alpha subunit-like effector A	50	104	3	21

Sequence references in MGI

J:47647 Inohara N, et al., CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998 May 1;17(9):2526-33
J:85229 Zhou Z, et al., Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 2003 Sep;35(1):49-56
J:136384 Puri V, et al., Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7833-8
J:178919 Gong J, et al., Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol. 2011 Dec 12;195(6):953-63
J:181181 Wang W, et al., Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med. 2012;18(2):235-43
J:317940 Xu W, et al., Differential Roles of Cell Death-inducing DNA Fragmentation Factor-alpha-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes. J Biol Chem. 2016 Feb 26;291(9):4282-93
J:333971 Christianson JL, et al., Identification of the lipid droplet targeting domain of the Cidea protein. J Lipid Res. 2010 Dec;51(12):3455-62
J:333972 Barneda D, et al., The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix. Elife. 2015 Nov 26;4:e07485
J:333997 Qian K, et al., CLSTN3beta enforces adipocyte multilocularity to facilitate lipid utilization. Nature. 2023 Jan;613(7942):160-168