Sequence Detail

ID/Version

O70263 Q8BRI8 Q8CFR3 O70264 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase LNX; EC=2.3.2.27;AltName: Full=Ligand of Numb protein X 1;AltName: Full=Ligand of Numb-binding protein 1;AltName: Full=Numb-binding protein 1;AltName: Full=RING-type E3 ubiquitin transferase LNX {ECO:00003

Provider

SWISS-PROT

Sequence

Polypeptide 728 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lnx1	ligand of numb-protein X 1	29	101	3	12

Sequence references in MGI

J:46959 Dho SE, et al., The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX. J Biol Chem. 1998 Apr 10;273(15):9179-87
J:73901 Nie J, et al., LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J. 2002 Jan 15;21(1-2):93-102
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563