Sequence Detail

ID/Version

O55242 Q9JKU9 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Sigma non-opioid intracellular receptor 1;AltName: Full=Sigma 1-type opioid receptor; Short=Sigma1-receptor; Short=Sigma1R;

Provider

SWISS-PROT

Sequence

Polypeptide 223 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sigmar1	sigma non-opioid intracellular receptor 1	33	103	3	12

Sequence references in MGI

J:44925 Seth P, et al., Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun. 1997 Dec 18;241(2):535-40
J:47688 Pan YX, et al., Cloning and characterization of a mouse sigma1 receptor. J Neurochem. 1998 Jun;70(6):2279-85
J:89669 Langa F, et al., Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice. Eur J Neurosci. 2003 Oct;18(8):2188-96
J:94560 Hiramatsu M, et al., Involvement of kappa-opioid receptors and sigma receptors in memory function demonstrated using an antisense strategy. Brain Res. 2004 Dec 31;1030(2):247-55
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101844 Cendan CM, et al., Formalin-induced pain is reduced in sigma(1) receptor knockout mice. Eur J Pharmacol. 2005 Mar 21;511(1):73-4
J:159702 Mavlyutov TA, et al., The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study. Neuroscience. 2010 May 5;167(2):247-55
J:197477 Kourrich S, et al., Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell. 2013 Jan 17;152(1-2):236-47
J:243881 Bernard-Marissal N, et al., Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration. Brain. 2015 Apr;138(Pt 4):875-90
J:261054 Su TC, et al., The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury. Neuropharmacology. 2016 Jun;105:1-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89