Sequence Detail

ID/Version

O55239 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nicotinamide N-methyltransferase {ECO:0000303|PubMed:24717514}; EC=2.1.1.1 {ECO:0000269|PubMed:26168293, ECO:0000269|PubMed:29483571};

Provider

SWISS-PROT

Sequence

Polypeptide 264 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nnmt	nicotinamide N-methyltransferase	23	98	3	12

Sequence references in MGI

J:43687 Yan L, et al., Mouse liver nicotinamide N-methyltransferase: cDNA cloning, expression, and nucleotide sequence polymorphisms. Biochem Pharmacol. 1997 Nov 15;54(10):1139-49
J:49397 Yan L, et al., Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization. DNA Cell Biol. 1998 Aug;17(8):659-67
J:208844 Kraus D, et al., Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10;508(7495):258-62
J:228760 Hong S, et al., Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94
J:263087 Kannt A, et al., A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2018 Feb 26;8(1):3660