Sequence Detail

ID/Version

O55236 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=mRNA-capping enzyme;AltName: Full=HCE;AltName: Full=MCE1;Includes: RecName: Full=mRNA 5'-triphosphate monophosphatase; EC=3.6.1.74 {ECO:0000269|PubMed:21683636}; AltName: Full=mRNA 5'-phosphatase;Includes: RecName: Full=mRNA gua

Provider

SWISS-PROT

Sequence

Polypeptide 597 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rngtt	RNA guanylyltransferase and 5'-phosphatase	36	98	3	30

Sequence references in MGI

J:50704 McCracken S, et al., 5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II [see comments]. Genes Dev. 1997 Dec 15;11(24):3306-18
J:51750 Yue Z, et al., Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II [see comments]. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12898-903
J:69577 Changela A, et al., Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme. EMBO J. 2001 May 15;20(10):2575-86
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89