Sequence Detail

ID/Version

O55042 Q3U130 Q9EQC3 Q9QUR3 Q9CXF8 (UniProt | EBI)

Last sequence update: 2001-04-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Alpha-synuclein;AltName: Full=Non-A beta component of AD amyloid;AltName: Full=Non-A4 component of amyloid precursor; Short=NACP;

Provider

SWISS-PROT

Sequence

Polypeptide 140 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Snca	synuclein, alpha	285	111	2	34

Sequence references in MGI

J:48620 Hsu LJ, et al., Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem. 1998 Jul;71(1):338-44
J:49927 Hong L, et al., The cDNA cloning and ontogeny of mouse alpha-synuclein. Neuroreport. 1998 Apr 20;9(6):1239-43
J:60151 Abeliovich A, et al., Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron. 2000 Jan;25(1):239-52
J:68015 Touchman JW, et al., Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element. Genome Res. 2001 Jan;11(1):78-86
J:93686 Schluter OM, et al., Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuroscience. 2003;118(4):985-1002
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:136786 Ihara M, et al., Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. 2007 Feb 15;53(4):519-33
J:147239 Inglis KJ, et al., Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem. 2009 Jan 30;284(5):2598-602
J:164218 Burre J, et al., Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science. 2010 Sep 24;329(5999):1663-7
J:216463 Burre J, et al., alpha-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4274-83
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89